Manchester United will be without all four of their recognised strikers for the FA Cup quarter-final clash with Chelsea this evening.
Following a collision with Phil Jones in training yesterday, captain Wayne Rooney is the most recent victim of United's striker crisis, with Ibrahimović serving the first of his three-game ban tonight, Martial missing out due to injury and Rashford suffering from illness.
This cup tie will be the first time Mourinho returns to Stamford Bridge after his side's 4-0 drumming at the hands of Conte's league runaways.
And The Special One's return will not be made easier without a recognised target man leading the line.
So, what are the options for José tonight?
With all four natural strikers out of action tonight, Mourinho may be forced to play Fellaini up front.
The Belgian, often utilised as a target man during the final moments of play during both the Van Gaal era and Mourinho's tenure, is the most natural fit for the role having played as a supporting striker during his Everton days.
Often the villain amongst fans, Fellaini's mercurial nature, sluggish movement and lack of silk-smooth football may be an ill-fit for a position that's been occupied by the worldly Zlatan this season.
However, if Mourinho plans to do a "Mourinho" tonight and park ten men behind the ball, having a large presence to hold up play, be the focal point for route one football and occupy towering defenders such as Cahill may not be a bad thing.
After all, Fellaini brings aerial presence and uncontrolled chaos to this United side, not to mention chest control that can absorb a universe.
Although it would be the least aesthetically appealing option, our bets are on Fellaini to start as United's frontman tonight.
Meanwhile, Eden Hazard has predicted Manchester United will have a strong finish to the season ahead of their FA Cup clash with Chelsea on Monday night.
The Belgian has shone for Antonio Conte's side, who find themselves well-placed to challenge for the double.
Chelsea's No.10 believes Jose Mourinho's side will be the 'best team in the second half of the season' and that Mourinho will be out for revenge following the 4-0 humbling from earlier in the season
“One month ago I told people that I thought United will be the best team in the second half of the season,” Hazard told the Telegraph. “Because they started slow, and then they have great players, a great manager, and they know what to do.