Police say there are a "number of confirmed fatalities" after reports of an explosion at Manchester Arena.
Police and emergency services are responding to what authorities say is a "serious incident" at the arena, where popular singer Ariana Grande performed on Monday.
"Details of a casualty bureau will follow as soon as available," officials said on Twitter.
"Due to an incident involving the emergency services [Manchester Victoria] has been evacuated," Northern train service officials said.
"We will provide further updates when possible."
The Duke of Edinburgh is retiring from royal duties this autumn, Buckingham Palace has announced.
The decision was made by Prince Philip himself and is supported by the Queen, a palace spokesman said.
The duke, who turns 96 next month, will attend previously scheduled engagements between now and August but will not accept new invitations.
The Queen "will continue to carry out a full programme of official engagements", the palace said.
Chelsea have moved a step closer to the Premier League title after a 4-2 home win over Southampton.
The Blues move seven points clear of Tottenham, although Spurs have a game in hand to come against Crystal Palace at Selhurst Park on Wednesday in which they could close the gap back down to four points.
Eden Hazard, whose perceived lack of selfishness in front of goal was a pre-match talking point, gave Chelsea the lead after just five of minutes of action with a low shot.
Today marks ten years since Trinidad and Tobago's Soca Warriors played a game that will be remembered for many years, the 2006 Germany World Cup clash against England in Nurnburg.
As the smallest nation to ever qualify for the World Cup, the Dwight Yorke-led Warriors were expected to suffer a heavy defeat to the powerful English.
But coming off a draw with Sweden in the first group game, T&T held England for as long as 82 minutes (8 minutes before the end of play), before Peter Crouch scored with a close range header.
The West Indies have won their opening fixture of the T20 World Cup against England in Mumbai, with Chris Gayle setting two records for sixes in the process.
The West Indies were set 183 runs to win by England, after the West Indies won the toss and decided to bowl.
England scored 182 for 6.
The West Indies in reply, made 183 for 4 off 18.1 balls, with Chris Gayle, taking just 47 balls to reach 100, ending the game at that score not out.