Chelsea condemned Middlesbrough to relegation and moved within one victory of the Premier League title with a 3-0 win at Stamford Bridge.
Diego Costa scored the opener – his 20th league goal of the season – as the Blues’ eased to a comfortable victory which saw Boro join Sunderland in dropping down to the Championship.
Marcos Alonso then doubled the home’s side lead after Brad Guzan failed to deal with his shot in the first half.
Chelsea have moved a step closer to the Premier League title after a 4-2 home win over Southampton.
The Blues move seven points clear of Tottenham, although Spurs have a game in hand to come against Crystal Palace at Selhurst Park on Wednesday in which they could close the gap back down to four points.
Eden Hazard, whose perceived lack of selfishness in front of goal was a pre-match talking point, gave Chelsea the lead after just five of minutes of action with a low shot.
Chelsea capitalised on Ander Herrera's sending-off to win a hard-fought FA Cup quarter-final with holders Manchester United and maintain their pursuit of a domestic double.
Herrera's dismissal for two fouls on Eden Hazard gave the advantage to the Blues midway through the first half.
The brilliant N'Golo Kante fired home the only goal - his second this season, both of which have been against United.
Chelsea dominated thereafter but spurned chances to add to their lead.
Manchester United will be without all four of their recognised strikers for the FA Cup quarter-final clash with Chelsea this evening.
Following a collision with Phil Jones in training yesterday, captain Wayne Rooney is the most recent victim of United's striker crisis, with Ibrahimović serving the first of his three-game ban tonight, Martial missing out due to injury and Rashford suffering from illness.
This cup tie will be the first time Mourinho returns to Stamford Bridge after his side's 4-0 drumming at the hands of Conte's league runaways.